Species-specific antibiotic-ribosome interactions:implications for drug development. Wilson DN, Harms JM, Nierhaus KH, Schlünzen F and Fucini P. –> Biological Chemistry, 386, 12, Dec. 2005.
Antibiotic Action On The Translational Apparatus. J.M. Harms, H. Bartels, F. Schlünzen and A. Yonath. –> J.Cell.Sci.,116, 1391-1393 (2003).(free access)
Translational regulation via L11: Molecular switches on the ribosome turned on and off by thiostrepton and micrococcin. Harms J.M.*, Wilson D.N.*, Schluenzen F.*, Connell S.R., Stachelhaus T., Zaborowska Z., Spahn C.M.T. and Fucini P. –> Molecular Cell, 30(1):26-38 (2008) Offizielle Pressemitteilung der J.W.-Goethe-Univ. Frankfurt a.M.: –> „Störung der Proteinfabrik“ — bei IDW-online als –> „Störfall in der Proteinfabrik“.
A snapshot of the 30S ribosomal subunit capturing mRNA via the Shine-Dalgarno interaction. Kaminishi T.*, Wilson DN.* , Takemoto C.*, Harms JM.*, Kawazoe M., Schluenzen F., Hanawa-Suetsugu K., Shirouzu M., Fucini P. and Yokoyama S. –>Structure. 2007 Mar;15(3):289-97.
The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. Schluenzen F, Takemoto C, Wilson DN, Kaminishi T, Harms JM, Hanawa-Suetsugu K, Szaflarski W, Kawazoe M, Shirouzu M, Nierhaus KH, Yokoyama S, Fucini P. –> Nat Struct Mol Biol. 2006 Oct;13(10):871-8. Epub 2006 Sep 24. MPI für molek. Genetik Presseinfo: –> Struktur eines Ribosom-Antibiotikum-Komplexes aufgeklärt (PDF)
The Binding Mode of the Trigger Factor on the Ribosome: Implications for Protein Folding and SRP Interaction Frank Schlünzen, Daniel N. Wilson, Pingsheng Tian, Jörg M. Harms, Stuart J. McInnes, Harly A.S. Hansen, Renate Albrecht, Jörg Buerger, Sigurd M. Wilbanks, and Paola Fucini. –> Structure , Vol 13, 1685-1694, November 2005.
Structural Basis for the Function of the Ribosomal L7/12 Stalk in Factor Binding and GTPase Activation. Mihaela Diaconu*, Ute Kothe*, Frank Schlünzen, Niels Fischer, Jörg M. Harms, Alexander G. Tonevitsky, Holger Stark, Marina V. Rodnina, and Markus C. Wahl. –> Cell, Vol 121, 991-1004, 1 July 2005 Max-Planck-Gesellschaft Presse-Information: –>Die kleinste Angelrute der Welt — HASYLAB Research Highlight: Puzzling the ribosome –> (PDF)
Inhibition of Peptide Bond Formation by Pleuromutilins: the Structure of the 50S Ribosomal Subunit from Deinococcus radiodurans in Complex with Tiamulin F. Schlünzen, E. Pyetan, P. Fucini, A. Yonath and J.M. Harms. –> Molecular Microbiology, 54(5), 1287-1294, 2004.
Structural insight into the antibiotic action of telithromycin on resistant mutants R. Berisio, J. Harms, F. Schluenzen, R. Zarivach, H. A.S. Hansen, P. Fucini and A. Yonath J. Bacteriol, 185, 4276-9 (2003).
Structural insight into the dynamic role of the ribosomal tunnel in cellular regulation. R. Berisio, F. Schlünzen, J. Harms, A. Bashan, T. Auerbach, D. Baram and A. Yonath. –> Nature Structural Biology, 10(5), 366-370, 2003. (PDF)
Structural basis for the antibiotic activity of ketolides and azalides. F. Schlünzen*, J.M. Harms*, F. Franceschi, H.A.S. Hansen, H. Bartels, R. Zarivach and A. Yonath. –> Structure , 11, 329-338 (2003).
Structural Basis for Peptidyl Transferase Activity and Inhibition by Puromycin and Sparsomycin A. Bashan, R. Zarivach, I. Agmon, F. Schlünzen, J. Harms, H. Bartels, F. Franceschi, H.A.S. Hansen, E. Kossoy, M. Kessler and A. Yonath. –> Mol.Cell , 11, 91-102 (2003).
High resolution structure of the large ribosomal subunit from a mesophilic eubacterium. J. Harms*, F. Schluenzen*, R. Zarivach*, A. Bashan, S. Gat, I. Agmon, H. Bartels, F. Franceschi & A. Yonath. –> Cell, 107, 679-688 (2001).
The crystal structure of complexes of the small ribosomal subunit with tetracycline, edeine and IF3. M. Pioletty*, F. Schluenzen*, J. Harms*, M. Gluehmann, R. Zarivach, A. Bashan, H. Bartels, T. Auerbach, F. Franceschi and A.Yonath. –> EMBO J., 20, 1829-1839 (2001).
Structure of a functionally activated small ribosomal subunit at 3.3 A resolution. F. Schluenzen*, A. Tocilj*, R. Zarivach, J. Harms, M. Gluehmann, D. Janell, A. Bashan, H. Bartels, I. Agmon, F. Franceschi & A. Yonath. Cell, 102, 615-623 (2000).
The small ribosomal subunit from Thermus thermophilus at 4.5 A resolution: Pattern fittings and the identification of a functional site. A. Tocilj*, F. Schluenzen*, H.A.S. Hansen, A. Bashan, D. Janell, M. Gluehmann, H. Bartels, J. Harms, I. Agmon, F. Franceschi, and A. Yonath. Proc NatlAcad Sci USA, 96, 14252-7 (1999).
Elucidating the medium-resolution structure of ribosomal particles: an interplay between electron cryo-microscopy and X-ray crystallograhy. J. Harms*, A. Tocilj*, I. Levin*, I. Agmon, H. Stark, I. Koelln, M. van Heel, M. Cuff, F. Schluenzen, A. Bashan, F. Franceschi, and A. Yonath. Structure 7, 931-41, (1999).
Crystallographic studies on the ribosome, a large macromolecular assembly exhibiting severe nonisomorphism, extreme beam sensitivity and no internal symmetry. A. Yonath, J. Harms, H.A.S. Hansen, A. Bashan, F. Schluenzen, I. Levin, I. Koelln, A. Tocilj, I. Agmon, M. Peretz, H. Bartels, W. S. Bennett, S. Krumbholz, D. Janell, S. Weinstein, T. Auerbach, H. Avila, M. Piolleti, S. Morlang, and F. Franceschi. Acta Crystallogr A, 54, 945-55 (1998).
The Effect of Cryogenic Treatment on the Cell Dimensions of Ribosomal Crystals. J. Harms, F. Schluenzen, K. von Boehlen, J. Thygesen, S. Meyer, I. Dunkel, B. Donzelmann, H.A.S. Hansen, A. Zaytzev-Bashan, A. Dribin, G. Kryger, G. Thoms, N. Volkmann, H. Bartels, W. S. Bennett & A. Yonath. ESF Report (K. Wilson Ed.) 26 (1993).
